USING THE METHOD KINESIOTAPING IN REHABILITATION OF CHILDREN WITH HEMIPARETIC FORM OF CEREBRAL PALSY

The study examines the impact of a new kind of impact in the rehabilitation of hemiparetic form of cerebral palsy – a method kinesiotaping “Concept 4 tapes.” Within this framework, the receptor patient unit gradually turned on, resulting in a restructuring of the program abnormal movement, the conditions of use of other methods to increase the efficiency and depth of the order of their influence.The advantage of a technique kinesiotaping is the standard approach, allowing you to apply effects diagram method to all patients without loss of efficacy of therapeutic effects

YARN : spinning-in-progress

YARN (Yet Another RussNet), a project started in 2013, aims at creating a large open WordNet-like thesaurus for Russian by means of crowdsourcing. The first stage of the project was to create noun synsets. Currently, the resource comprises 100K+ word entries and 46K+ synsets. More than 200 people have taken part in assembling synsets throughout the project. The paper describes the linguistic, technical, and organizational principles of the project, as well as the evaluation results, lessons learned, and the future plans

Wave Function Shredding by Sparse Quantum Barriers

We discuss a model in which a quantum particle passes through $\delta$ potentials arranged in an increasingly sparse way. For infinitely many barriers we derive conditions, expressed in terms ergodic properties of wave function phases, which ensure that the point and absolutely continuous parts are absent leaving a purely singularly continuous spectrum. For a finite number of barriers, the transmission coefficient shows extreme sensitivity to the particle momentum with fluctuation in many different scales. We discuss a potential application of this behavior for erasing the information carried by the wave function.Comment: 4 pages ReVTeX with 3 epsf figure

Tailed skyrmions -- an obscure branch of magnetic solitons

We report tailed skyrmions -- a new class of stable soliton solutions of the 2D chiral magnet model. Tailed skyrmions have elongated shapes and emerge in a narrow range of fields near the transition between the spin spirals and the saturated state. We analyze the stability range of these solutions in terms of external magnetic field and magnetocrystalline anisotropy. Minimum energy paths and the homotopies (continuous transitions) between tailed skyrmions of the same topological charge have been calculated using the geodesic nudged elastic bands method. The discovery of tailed skyrmions extends the diversity of already-known solutions illustrated by complex morphology solitons, such as tailed skyrmion bags with and without chiral kinks.Comment: 7 pages, 6 figure

Thermal generation of droplet soliton in chiral magnet

Controlled creation of localized magnetic textures beyond conventional π-skyrmions is an important problem in the field of magnetism. Here, by means of spin dynamics simulations, Monte Carlo simulations, and harmonic transition state theory we demonstrate that an elementary chiral magnetic soliton with zero topological charge—the chiral droplet—can be created by thermal fluctuations in the presence of the tilted magnetic field. The proposed protocol relies on an unusual kinetics combining the effects of the entropic stabilization and low-energy barrier for the nucleation of a topologically trivial state. Following this protocol by varying temperature and the tilt of the external magnetic field, one can selectively generate chiral droplets or π-skyrmions in a single system. The coexistence of two distinct magnetic solitons establishes a basis for a rich magnetization dynamics and opens up the possibility for the construction of more complex magnetic textures such as skyrmion bags and skyrmions with chiral kinks.Deutsche Forschungsgemeinschaft (DFG) through SPP 2137 "Skyrmionics" Grant No. KI 2078/1-1, the Russian Science Foundation (Grant No. 19-72-10138), the Icelandic Research Fund (Grant Nos. 184949 and 217750), the University of Iceland Research Fund (Grant No. 15673), and the Swedish Research Council (Grant No. 2020-05110)Peer Reviewe

Thermal generation of droplet soliton in chiral magnet

Controlled creation of localized magnetic textures beyond conventional π-skyrmions is an important problem in the field of magnetism. Here, by means of spin dynamics simulations, Monte Carlo simulations, and harmonic transition state theory we demonstrate that an elementary chiral magnetic soliton with zero topological charge—the chiral droplet—can be created by thermal fluctuations in the presence of the tilted magnetic field. The proposed protocol relies on an unusual kinetics combining the effects of the entropic stabilization and low-energy barrier for the nucleation of a topologically trivial state. Following this protocol by varying temperature and the tilt of the external magnetic field, one can selectively generate chiral droplets or π-skyrmions in a single system. The coexistence of two distinct magnetic solitons establishes a basis for a rich magnetization dynamics and opens up the possibility for the construction of more complex magnetic textures such as skyrmion bags and skyrmions with chiral kinks.Deutsche Forschungsgemeinschaft (DFG) through SPP 2137 "Skyrmionics" Grant No. KI 2078/1-1, the Russian Science Foundation (Grant No. 19-72-10138), the Icelandic Research Fund (Grant Nos. 184949 and 217750), the University of Iceland Research Fund (Grant No. 15673), and the Swedish Research Council (Grant No. 2020-05110)Peer Reviewe

Characterizing and prognosticating chronic lymphocytic leukemia in the elderly: prospective evaluation on 455 patients treated in the United States.

BACKGROUND: Median age at diagnosis of patients with chronic lymphocytic leukemia (CLL) is \u3e 70 years. However, the majority of clinical trials do not reflect the demographics of CLL patients treated in the community. We examined treatment patterns, outcomes, and disease-related mortality in patients ≥ 75 years with CLL (E-CLL) in a real-world setting. METHODS: The Connect® CLL registry is a multicenter, prospective observational cohort study, which enrolled 1494 adult patients between 2010-2014, at 199 US sites. Patients with CLL were enrolled within 2 months of initiating first line of therapy (LOT1) or a subsequent LOT (LOT ≥ 2). Kaplan-Meier methods were used to evaluate overall survival. CLL- and infection-related mortality were assessed using cumulative incidence functions (CIF) and cause-specific hazards. Logistic regression was used to develop a classification model. RESULTS: A total of 455 E-CLL patients were enrolled; 259 were enrolled in LOT1 and 196 in LOT ≥ 2. E-CLL patients were more likely to receive rituximab monotherapy (19.3 vs. 8.6%; p \u3c 0.0001) and chemotherapy-alone regimens (p \u3c 0.0001) than younger patients. Overall and complete responses were lower in E-CLL patients than younger patients when given similar regimens. With a median follow-up of 3 years, CLL-related deaths were higher in E-CLL patients than younger patients in LOT1 (12.6 vs. 5.1% p = 0.0005) and LOT ≥ 2 (31.3 vs. 21.5%; p = 0.0277). Infection-related deaths were also higher in E-CLL patients than younger patients in LOT1 (7.4 vs. 2.7%; p = 0.0033) and in LOT ≥ 2 (16.2 vs. 11.2%; p = 0.0786). A prognostic score for E-CLL patients was developed: time from diagnosis to treatment \u3c 3 months, enrollment therapy other than bendamustine/rituximab, and anemia, identified patients at higher risk of inferior survival. Furthermore, higher-risk patients experienced an increased risk of CLL- or infection-related death (30.6 vs 10.3%; p = 0.0006). CONCLUSION: CLL- and infection-related mortality are higher in CLL patients aged ≥ 75 years than younger patients, underscoring the urgent need for alternative treatment strategies for these understudied patients. TRIAL REGISTRATION: The Connect CLL registry was registered at clinicaltrials.gov: NCT01081015 on March 4, 2010

Hybrid Spider Silk with Inorganic Nanomaterials

High-performance functional biomaterials are becoming increasingly requested. Numerous natural and artificial polymers have already demonstrated their ability to serve as a basis for bio-composites. Spider silk offers a unique combination of desirable aspects such as biocompatibility, extraordinary mechanical properties, and tunable biodegradability, which are superior to those of most natural and engineered materials. Modifying spider silk with various inorganic nanomaterials with specific properties has led to the development of the hybrid materials with improved functionality. The purpose of using these inorganic nanomaterials is primarily due to their chemical nature, enhanced by large surface areas and quantum size phenomena. Functional properties of nanoparticles can be implemented to macro-scale components to produce silk-based hybrid materials, while spider silk fibers can serve as a matrix to combine the benefits of the functional components. Therefore, it is not surprising that hybrid materials based on spider silk and inorganic nanomaterials are considered extremely promising for potentially attractive applications in various fields, from optics and photonics to tissue regeneration. This review summarizes and discusses evidence of the use of various kinds of inorganic compounds in spider silk modification intended for a multitude of applications. It also provides an insight into approaches for obtaining hybrid silk-based materials via 3D printing

Real-world clinical experience in the Connect® chronic lymphocytic leukaemia registry: a prospective cohort study of 1494 patients across 199 US centres.

The clinical course of chronic lymphocytic leukaemia (CLL) is heterogeneous, and treatment options vary considerably. The Connect® CLL registry is a multicentre, prospective observational cohort study that provides a real-world perspective on the management of, and outcomes for, patients with CLL. Between 2010 and 2014, 1494 patients with CLL and that initiated therapy, were enrolled from 199 centres throughout the USA (179 community-, 17 academic-, and 3 government-based centres). Patients were grouped by line of therapy at enrolment (LOT). We describe the clinical and demographic characteristics of, and practice patterns for, patients with CLL enrolled in this treatment registry, providing patient-level observational data that represent real-world experiences in the USA. Fluorescence in situ hybridization (FISH) analyses were performed on 49·3% of patients at enrolment. The most common genetic abnormalities detected by FISH were del(13q) and trisomy 12 (45·7% and 20·8%, respectively). Differences in disease characteristics and comorbidities were observed between patients enrolled in LOT1 and combined LOT2/≥3 cohorts. Important trends observed include the infrequent use of genetic prognostic testing, and differences in patient characteristics for patients receiving chemoimmunotherapy combinations. These data represent experiences of patients with CLL in the USA, which may inform treatment decisions in everyday practice

PFKFB3 overexpression in monocytes of patients with colon but not rectal cancer programs pro-tumor macrophages and is indicative for higher risk of tumor relapse

IntroductionCirculating monocytes are main source for tumor-associated macrophages (TAMs) that control tumor growth, angiogenesis, metastasis and therapy resistance. We raised the questions how monocyte programming is affected by growing tumors localized in colon and rectal sections, and how treatment onsets affect monocyte programming in the circulation.MethodsPatients with rectal cancer and colon cancer were enrolled in the study. Peripheral blood monocytes were characterized by phenotypic analysis using flow cytometry, by transcriptomic analysis using RNA sequencing and by gene expression analysis using real-time RT-PCR. Phenotypic analysis was performed with IF/confocal microscopy. Spatial transcriptomic analysis was applied using GeoMX DSP-NGS.ResultsIn patients with rectal cancer, increased amount of CCR2+ monocytes was indicative for the absence of both lymphatic and hematogenous metastasis. In contrast, in patients with colon cancer CD163+ monocytes were indicative for LN metastasis. NGS analysis identified tumor-specific transcriptional programming of monocytes in all CRC patients compared to healthy individuals. The key transcriptional difference between monocytes of patients with colon and rectal cancer was increased expression of PFKFB3, activator of glycolysis that is currently considered as therapy target for major solid cancers. PFKFB3-expressing monocyte-derived macrophages massively infiltrated tumor in colon. Nanostring technology identified correlation of PFKFB3 with amount and tumor-promoting properties of TAMs in colon but not in rectal cancer. PFKFB3 was indicative for tumor relapse specifically in colon cancer.DiscussionOur findings provide essential argument towards CRC definition to cover two clinically distinct cancers – colon cancer and rectal cancer, that differentially interact with innate immunity